Rationale for the use of Anti-inflammatories

Eye Co is employing two compounds with proven anti inflammatory effects:

• Fludrocortisone acetate (FA)
  (ref: Experimental Eye Research 212 (2021), 108765). Refer to Reference Data tab on this Website for full text.

• Hemp seed oil
  (ref: Deloitte Access Economics: Eyes to the Future (2011). Refer to Reference Data tab on this Website for full report.

Eye Co is targeting four retinal disease indications involving inflammation:

• DME: involves overproduction of VEGF, (pro-inflammatory cytokine). Excessive anti-VEGF treatment results in MA.
• Dry-AMD: involves chronic inflammation resulting in Geographic Atrophy (GA). Eye Co’s Fludrocortisone Acetate (FA) safety study has been successfully completed in patients with GA.
• Wet-AMD refractile to anti-VEGF. Eye Co is planning to employ FA in combination with anti-VEGF technologies.
• Early AMD: Regular consumption of omega oils is known to reduce the risk of disease progression. Eye Co intends to study the effect of omega rich anti-inflammatory hemp seed oil in early AMD